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This delayed emptying contributes to the satiety effect that helps patients eat less, but it also drives the nausea, vomiting, and constipation reported in the SURPASS-1 trial (N=478), where nausea occurred in 12.8% of patients on tirzepatide 5 mg and 18.6% on 15 mg, versus 6.0% on placebo [4]
Better options exist
doi: 10.3390/md17070405 164 TricaB.TriteanN.Constantinescu-AruxandeiD.OanceaF
The SURMOUNT and SURPASS trials showed tirzepatide may produce greater weight loss than semaglutide at comparable doses
Its very hard to explain how your body tells you if you've not experienced this
If this moves forward, eligible patients could see out-of-pocket costs capped at approximately $50 per month
